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2025

 

  • Abazid A, Babak A, Huschitt N, Badendieck S, Stope MB (2025) Application of non-invasive physical plasma in an in vitro tissue model of fibroblasts and epithelial cells: enhanced cell adhesion in mesh implants. Wehrmed Monatsschr 69:6-12

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  • Eichler J, Rulik B, Abazid A, Stope MB (2025) Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs. Sci Rep 15:2744

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  • Dejonckheere CS, Layer JP, Sarria GR, Wiegreffe S, Glasmacher AR, Nour Y, Scafa D, Müdder T, Anzböck T, Giordano FA, Stope MB, Schmeel LC, Gkika E (2025) Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: study protocol for a phase 3 randomised double-blind placebo-controlled trial (NIPP-RD III). Trials 26:97

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  • Wang Y, Eggers B, Abazid A, Erb HHH, Stope MB (2025). Non-invasive physical plasma as an oncological therapy option: modulation of cancer cell growth, motility, and metabolism without induction of cancer resistance factors. Cancers 17:3517

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2024

 

  • Dejonckheere CS, Layer JP, Nour Y, Layer K, Glasmacher A, Wiegreffe S, Fuhrmann A, Caglayan L, Grau F, Sarria GR, Scafa D, Koch D, Heimann M, Leitzen C, Köksal MA, Röhner F, Müdder T, Dejonckheere E, Schmeel FC, Anzböck T, Lindner K, Bachmann A, Abramian A, Kaiser C, Faridi A, Mustea A, Giordano FA, Stope MB, Schmeel LC (2024) Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: Results from an intrapatient-randomised double-blind placebo-controlled trial. Clin Transl Radiat Oncol 44:100699

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  • Eggers B, Seher L, Marciniak J, Pauck T, Deschner J, Eick S, Stope MB, Kramer FJ, Calvano Küchler E, Kirschneck C, Nokhbehsaim M, Beisel-Memmert S (2024) Beneficial effects of non-invasive physical plasma on human periodontal ligament cells in vitro. Front Med 11:1443368

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  • Gelbrich N, Muhtadi R, Scherthan H, Stope MB (2024) Short-term effects of non-invasive physical plasma treatment on genomic stability. In Vivo 38:82-89

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  • Röcker R, Eggers B, Kramer A, Stope MB (2024) Effective manual cleaning as the first step of reprocessing glass probes of a medical device for non-invasive physical plasma therapy. GMS Hyg Infect Control 19:Doc31

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  • Niu Y, Förster S, Badendieck S, Nokhbehsaim M, Abazid A, Stope MB (2024) Non-invasive physical plasma modulates macrophage polarization: A potential strategy for tumor microenvironment remodeling. Anticancer Res 44:2437-2444

 

 

2023

 

 

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  • Eggers B, Stope MB, Marciniak J, Mustea A, Eick S, Deschner J, Nokhbehsaim M, Kramer FJ (2023) Non-invasive physical plasma reduces inflammatory response in microbially prestimulated gingival cells. Int J Mol Sci 24:16156

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  • Dejonckheere CS, Schmeel LC, Stope MB (2023) Concise review of non-invasive physical plasma as a promising treatment option for radiation injuries of the skin. Wound Rep Reg 31:415-417

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  • Wang Y, Abazid A, Badendieck S, Mustea A, Stope MB (2023) Impact of non-invasive physical plasma on heat shock protein functionality in eukaryotic cells. Biomedicines 11:1471

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  • Förster S, Niu Y, Eggers B, Nokhbehsaim M, Kramer FJ, Bekeschus S, Mustea A, Stope MB (2023) Modulation of the tumor-associated immuno-environment by non-invasive physical plasma. Cancers 15:1073

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  • Nitsch A, Sander C, Eggers B, Weiss M, Egger EK, Kramer FJ, Erb HHH, Mustea A, Stope MB (2023) Pleiotropic devitalization of renal cancer cells by non-invasive physical plasma: Characterization of molecular and cellular efficacy. Cancers 15:481

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  • Lehmann S, Bien-Möller S, Marx S, Bekeschus S, Schroeder HWS, Mustea A, Stope MB (2023) Devitalization of glioblastoma cancer cells by non-invasive physical plasma: modulation of proliferative signalling cascades. Anticancer Res 43:7-18

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  • Gelbrich N, Miebach L, Berner J, Freund E, Saadati F, Schmidt A, Stope MB, Zimmermann U, Burchardt M, Bekeschus S (2023) Medical gas plasma augments bladder cancer cell toxicity in preclinical models and patient-derived tumor tissues. J Adv Res 47:209-223

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2022

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  • Singer D, Wulff CP, Stope MB, Bekeschus S (2022) Extracellular heat shock protein 27 is released by plasma-treated ovarian cancer cells and affects THP-1 monocyte activity. Plasma 5:569–578

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  • Eggers B, Stope MB, Röcker R, Mustea A, Kramer FJ (2022) Zur Anwendung von Nicht-Invasivem Physikalischem Plasma in der Zahnmedizin. Zahnarzt Wirtschaft Praxis 10/2022:66-72

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  • Singer D, Ressel V, Stope MB, Bekeschus M (2022) Heat shock protein 27 affects myeloid cell activation and interaction. Biomedicines 10:2192

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  • Eggers B, Stope MB, Marciniak J, Mustea A, Deschner J, Nokhbehsaim M, Kramer FJ (2022) Modulation of inflammatory responses by a non-invasive physical plasma jet during gingival wound healing. Cells 11:2740

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  • Dejonckheere CS, Torres-Crigna A, Layer JP, Layer K, Wiegreffe S, Sarria GR, Scafa D, Koch D, Leitzen C, Köksal MA, Müdder T, Abramian A, Kaiser C, Faridi A, Stope MB, Mustea A, Giordano FA, Schmeel LC (2022) Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: a first-in-human feasibility study. Pharmaceutics 14:176

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  • Eggers B, Stope MB, Marciniak J, Götz W, Mustea A, Deschner J, Nokhbehsaim M, Kramer FJ (2022) Non-invasive physical plasma generated by a medical argon plasma device induces the expression of regenerative factors in human gingival keratinocytes, fibroblasts, and tissue biopsies. Biomedicines 10:889

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  • Marzi J*, Stope MB*, Henes M, Koch A, Wenzel T, Holl M, Layland SL, Neis F, Bösmüller H, Ruoff F, Templin M, Krämer B, Staebler A, Barz J, Carvajal Berrio DA, Enderle M, Loskill P, Brucker SY, Schenke-Layland K, Weiss M (2022) Non-invasive physical plasma (NIPP) as innovative and tissue-preserving therapy for women positive for cervical intraepithelial neoplasia. Cancers 14:1933

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  • Eggers B, Stope MB, Mustea A, Heim N, Kramer FJ (2022) Non-invasive physical plasma treatment after tooth extraction in a patient on antiresorptive medication promotes tissue regeneration. Appl Sci 12:3490

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  • Nitsch A, Strakeljahn S, Jacoby JM, Sieb K, Mustea A, Bekeschus S, Ekkernkamp A, Stope MB, Haralambiev L (2022) New approach against chondrosoma cells - cold plasma treatment inhibits cell motility and metabolism, and leads to apoptosis. Biomedicines 10:688

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  • Nitsch A, Napiletzki K, Stope MB (2022) Non-invasive physical plasma (NIPP) treatment of a hedgehog with head injury - a novel therapy in veterinary medicine. Vet Rec Case Rep 10:e343

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  • Bekeschus S, Ispirjan M, Freund E, Kinnen F, Moritz J, Saadati F, Eckroth J, Singer D, Stope MB, Wende K, Ritter CA, Schroeder HWS, Marx S (2022) Gas plasma technology targeting of glioblastoma multiforme (GBM) in vitro and patient-derived tumor tissues. Cancers 14:813

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2021

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  • Schütz CS, Stope MB, Bekeschus S (2021) H2A.X phosphorylation in oxidative stress and risk assessment in plasma medicine. Oxid Med Cell Longev 2021:2060986

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  • Nitsch A, Stope MB (2021) The future therapy of renal cell carcinoma? Non-invasive physical plasma as an innovative oncological therapy modality. J Cancer Ther 12:602-610

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  • Sander C, Nitsch A, Erb HHH, Egger EK, Haralambiev L, Eggers B, Kramer FJ, Weiss M, Mustea A, Stope MB (2021) Non-invasive physical plasma enhances the membrane permeability to low molecular weight compounds and subsequently leads to the loss of cellular ATP and the devitalization of epithelial cancer cells. Appl Sci 11:9801

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  • Eggers B, Marciniak J, Deschner J, Stope MB, Mustea A, Kramer FJ, Nokhbehsaim M (2021) Cold atmospheric plasma promotes regeneration-associated cell functions of murine cementoblasts in vitro. Int J Mol Sci 22:5280

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  • Gelbrich N, Burchardt M, Zimmermann U, Stope MB, Bekeschus S (2021) Kaltes atmosphärisches Plasma: Neue Behandlungsoption für Harnblasenkrebs. UroForum 9/2021:26-28

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  • Bekeschus S, Clemen R, Haralambiev L, Niessner F, Grabarczyk P, Weltmann KD, Menz J, Stope MB, von Woedtke T, Gandhirajan R, Schmidt A (2021) The plasma-induced leukemia cell death is dictated by the ROS chemistry and the HO-1/CXCL8 axis. IEEE Transactions on Radiation and Plasma Medical Sciences 5:398-411

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2020

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  • Haralambiev L, Neuffer O, Nitsch A, Kross NC, Bekeschus S, Hinz P, Mustea A, Ekkernkamp A, Gümbel D, Stope MB (2020) Inhibition of angiogenesis by treatment with cold atmospheric plasma as a promising therapeutic approach in oncology. Int J Mol Sci 21:7098

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  • Kletschkus K, Haralambiev L, Mustea A, Bekeschus S, Stope MB (2020) Review of innovative physical therapy methods: introduction to the principles of cold physical plasma. In Vivo 34:3103-3107

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  • Stope MB, Benouahi R, Sander C, Haralambiev L, Nitsch A, Egger E, Mustea A (2020) Protherapeutic effects and inactivation of mammary carcinoma cells by a medical argon plasma device. Anticancer Res 40:6205-6212

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  • Stope MB (2020) Plasma oncology - Physical plasma as innovative tumor therapy. J Cancer Biol 1:53-56

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  • Jacoby JM, Strakeljahn S, Nitsch A, Bekeschus S, Hinz P, Mustea A, Ekkernkamp A, Tzvetkov MV, Haralambiev L, Stope MB (2020) An innovative therapeutic option for the treatment of skeletal sarcomas: elimination of osteo- and Ewing's sarcoma cells using physical gas plasma. Int J Mol Sci 21:4460

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  • Kramer A, Meinke M, Patzelt A, Stope MB, Lademann J, Jacobs K (2020) Perspektiven physikalischer Verfahren der Antiseptik und Desinfektion. Hygiene & Medizin 45:39-45

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  • Haralambiev L, Bandyophadyay A, Suchy B, Weiss M, Kramer A, Bekeschus S, Ekkernkamp A, Mustea A, Kaderali L, Stope MB (2020) Determination of immediate vs. kinetic growth retardation in physically plasma-treated cells by experimental and modelling data. Anticancer Res 40:3743-3749

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  • Feil L, Koch A, Utz R, Ackermann M, Barz J, Stope MB, Krämer B, Wallwiener D, Brucker SY, Weiss M (2020) Cancer-selective treatment of cancerous and non-cancerous human cervical cell models by a non-thermally operated electrosurgical argon plasma device. Cancers 12:1037

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  • Bekeschus S, Ressel V, Freund E, Gelbrich N, Mustea A, Stope MB (2020) Gas plasma-treated prostate cancer cells augment myeloid cell activity and cytotoxicity. Antioxidants 9:323

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  • Kletschkus K, Haralambiev L, Nitsch A, Pfister F, Klinkmann G, Kramer A, Bekeschus S, Mustea A, Stope MB (2020) The application of a low-temperature physical plasma device operating under atmospheric pressure leads to the production of toxic NO2. Anticancer Res 40:2591-2599

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  • Haralambiev L, Nitsch A, Jacoby JM, Strakeljahn S, Bekeschus S, Mustea A, Ekkernkamp A, Stope MB (2020) Cold atmospheric plasma treatment of chondrosarcoma cells affects proliferation and cell membrane permeability. Int J Mol Sci 21:2291

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  • Kletschkus K, Gelbrich N, Burchardt M, Kramer A, Bekeschus S, Stope MB (2020) Emission of ultraviolet radiation from 220 to 280 nm by a cold physical plasma generating device. Health Phys 119:153-159

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  • Haralambiev L, Nitsch A, Einenkel R, Muzzio DO, Gelbrich N, Burchardt M, Zygmunt M, Ekkernkamp A, Stope MB, Gümbel D (2020) The effect of cold atmospheric plasma on the membrane permeability of human osteosarcoma cells. Anticancer Res 40:841-846

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  • Haralambiev L, Wien L, Gelbrich N, Lange J, Bakir S, Kramer A, Burchardt M, Ekkernkamp A, Gümbel D, Stope MB (2020) Cold atmospheric plasma inhibits the growth of osteosarcoma cells by induction of apoptosis, independent of the device used. Oncol Lett 19:283-290

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2019

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  • Bekeschus S, Schütz C, Nießner F, Wende K, Weltmann KD, Gelbrich N, Woedtke T, Schmidt A, Stope MB (2019) Elevated H2AX phosphorylation observed with kINPen plasma treatment is not caused by ROS-mediated DNA damage but is the consequence of apoptosis. Oxid Med Cell Longev 2019:8535163

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  • Gelbrich N, Nitsch A, Burchardt M, Stope MB (2019) Kaltes atmosphärisches Plasma - Antineoplastische Effekte auf Nierenzellkarzinom-Zellen. Urologische Nachrichten, 09/2019:5

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  • Freund E, Moritz J, Stope MB, Seebauer C, Schmidt A, Bekeschus S (2019) Plasma-derived reactive species shape a differentiation profile in human monocytes. Appl Sci 9:2530

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  • Weiss M, Barz J, Ackermann M, Utz R, Ghoul A, Weltmann KD, Stope MB, Wallwiener D, Schenke-Layland K, Oehr C, Brucker S, Loskill P (2019) Dose-dependent tissue-level characterization of a medical atmospheric pressure argon plasma jet. ACS Appl Mater Interfaces 11:19841-19853

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  • Gelbrich N, Stope MB (2019) Physikalisches Plasma in der chirurgischen Uroonkologie. Krankenhaus und Management 38:9

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  • Haralambiev L, Wien L, Gelbrich N, Kramer A, Mustea A, Burchardt M, Ekkernkamp A, Stope MB, Gümbel D (2019) Effects of cold atmospheric plasma on the expression of chemokines, growth factors, TNF superfamily members, interleukins, and cytokines in human osteosarcoma cells. Anticancer Res 39:151-157

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  • Riedel F, Weiss M, Stope MB (2019) Neue Möglichkeiten in der gynäkologischen Onkologie - kaltes physikalisches Plasma. Gynäkologe 52:144-146

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  • Gelbrich N, Stope MB, Burchardt M (2019) Kaltes atmosphärisches Plasma für die urologische Tumortherapie. Urologe A 58:673-679

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2018

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  • Bekeschus S, Wulf CP, Freund E, Koensgen D, Mustea A, Weltmann KD, Stope MB (2018) Plasma treatment of ovarian cancer cells mitigates their immuno-modulatory products active on THP-1 monocytes. Plasma 1:201-217

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  • Weiss M, Stope MB (2018) Physical plasma - a new treatment option in gynecological oncology. Arch Gynecol Obstet 298:853–855

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  • Daeschlein G, Hillmann A, Gümbel D, Sicher C, von Podewils S, Stope MB, Jünger M (2018) Enhanced anticancer efficacy by drug chemotherapy and cold atmospheric plasma against melanoma and glioblastoma cell lines in vitro. IEEE Transactions on Radiation and Plasma Medical Sciences 2:153-159

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  • Bender C, Kramer A, Stope MB (2018) Application in veterinary medicine. In: Comprehensive Clinical Plasma Medicine, Ed. Metelmann HR, von Woedtke T, Weltmann KD, Springer, Cham, 283-297

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2017

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  • Gümbel D, Daeschlein G, Napp M, Ekkernkamp A, Kramer A, Stope MB (2017) Cold atmospheric plasma in orthopaedic and urologic tumor therapy. GMS Hyg Infect Control 12:Doc10

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  • Koensgen D, Besic I, Gümbel D, Kaul A, Weiss M, Diesing K, Kramer A, Bekeschus S, Mustea A, Stope MB (2017) Cold atmospheric plasma (CAP) and CAP-stimulated cell culture media suppress ovarian cancer cell growth - a putative treatment option in ovarian cancer therapy. Anticancer Res 37:6739-6744

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  • Weiss M, Daeschlein G, Kramer A, Burchardt M, Brucker S, Wallwiener D, Stope MB (2017) Virucide properties of cold atmospheric plasma for future clinical applications. J Med Virol 89:952-959

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  • Gümbel D, Suchy B, Wien L, Gelbrich N, Napp M, Kramer A, Ekkernkamp A, Daeschlein G, Stope MB (2017) Comparison of cold atmospheric plasma devices' efficacy on osteosarcoma and fibroblastic in vitro cell models. Anticancer Res 37:5407-5414

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  • Gümbel D, Gelbrich N, Napp M, Daeschlein G, Kramer A, Sckell A, Burchardt M, Ekkernkamp A, Stope MB (2017) Peroxiredoxin expression of human osteosarcoma cells is influenced by cold atmospheric plasma treatment. Anticancer Res 37:1031-1038

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  • Gümbel D, Stope MB (2017) Plasmabehandlung maligner Knochen- und Weichteiltumoren sowie urologischer Tumoren. In: Plasma-Medizin - Neue Wege der Haut-, Wund- und Krebsbehandlung in Theorie und Praxis. Ed. Daeschlein G, UNI-MED Verlag, Bremen, 92-94

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  • Gümbel D, Bekeschus S, Gelbrich N, Napp M, Ekkernkamp A, Kramer A, Stope MB (2017) Cold atmospheric plasma in the treatment of osteosarcoma. Int J Mol Sci 18:E2004

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2016

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  • Gümbel D, Gelbrich N, Weiss M, Napp M, Daeschlein G, Sckell A, Ender SA, Kramer A, Burchardt M, Ekkernkamp A, Stope MB (2016) New treatment options for osteosarcoma - inactivation of osteosarcoma cells by cold atmospheric plasma. Anticancer Res 36:5915-5922

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  • Kluge S, Bekeschus S, Bender C, Benkai H, Skell A, Below H, Stope MB, Kramer A (2016) Investigating the mutagenicity of a cold argon-plasma jet in an HET-MN model. PLoS One 11:e0160667

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  • Bekeschus S, Rödder K, Schmidt A, Stope MB, von Woedtke T, Miller V, Fridman A, Weltmann KD, Masur K, Metelmann HR, Wende K, Hasse S (2016) Cold physical plasma selects for specific T helper cell subsets with distinct cell surface markers in a caspase-dependent and NFkB-independent manner. Plasma Process Polym 13:1144-1150

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2015

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  • Weiss M, Gümbel D, Gelbrich N, Brandenburg LO, Mandelkow R, Zimmermann U, Ziegler P, Burchardt M, Stope MB (2015) Inhibition of cell growth of the prostate cancer cell model LNCaP by cold atmospheric plasma. In Vivo 29:611-616

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  • Kramer A, Bekeschus S, Matthes R, Bender C, Stope MB, Napp M, Lademann O, Lademann J, Weltmann KD, Schauer F (2015) Cold physical plasmas in the field of hygiene – relevance, significance, and future applications. Plasma Process Polym 12:1410-142

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  • Weiss M, Gümbel D, Hanschmann EM, Mandelkow R, Gelbrich N, Zimmermann U, Walther R, Ekkernkamp A, Sckell A, Kramer A, Burchardt M, Lillig CH, Stope MB (2015) Cold atmospheric plasma treatment induces anti-proliferative effects in prostate cancer cells by redox and apoptotic signaling pathways. PLoS One 10:e0130350

Publikationen Physikalisches Plasma.
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